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納米抗體發(fā)現(xiàn)

納米抗體發(fā)現(xiàn)

羊駝駱駝免疫

文庫構(gòu)建

抗體篩選

蛋白表達(dá)純化

親和力檢測 (BLI)

人源化與親和力成熟

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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.
蛋白表達(dá)純化

蛋白表達(dá)純化

E.coli表達(dá)系統(tǒng)

酵母表達(dá)系統(tǒng)

哺乳動物細(xì)胞表達(dá)系統(tǒng)

昆蟲細(xì)胞表達(dá)系統(tǒng)

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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.
靶向GPCR藥物發(fā)現(xiàn)

靶向GPCR藥物發(fā)現(xiàn)

GPCR蛋白表達(dá)純化

基于冷凍電鏡的GPCR結(jié)構(gòu)解析

靶向GPCR的納米抗體藥物發(fā)現(xiàn)

GPCR蛋白產(chǎn)品

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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.
科研產(chǎn)品

科研產(chǎn)品

納米抗體系列

重組標(biāo)簽蛋白抗體

蛋白純化填料系列

感受態(tài)細(xì)胞系列

鏈霉親和素系列

SDS-PAGE/WB相關(guān)產(chǎn)品

PCR系列

自動誘導(dǎo)培養(yǎng)基

分子診斷酶

逆轉(zhuǎn)錄系列

抗體制備相關(guān)產(chǎn)品

羊駝天然文庫

重組蛋白酶

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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.
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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.
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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.
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Copyright ? 2023 深圳康體生物醫(yī)藥科技有限公司 All Rights Reserved. 粵ICP備17049240號-1.

靶向GPCR藥物發(fā)現(xiàn)

Targeted GPCR Drug Discovery

靶向GPCR藥物發(fā)現(xiàn)

GPCR簡介

GPCR(G蛋白偶連受體)是藥物研發(fā)領(lǐng)域的明星靶標(biāo)，目前有超700種獲批藥物靶向GPCR，約占目前所有獲批藥物的1/3GPCR在信號轉(zhuǎn)導(dǎo)中發(fā)揮著核心作用:癌癥、心臟病、糖尿病、阿爾茨海默病等危害人類健康的重大疾病均與GPCR密切相關(guān)。然而，在GPCR家族的800多個GPCR成員中，只有大約90個是已知的藥物靶點，包括孤兒受體在內(nèi)的近300個成員在新藥開發(fā)方面具有重要的價值與潛力。

GPCR蛋白表達(dá)純化

康體生命采用尖端的重組蛋白功能表達(dá)和純化技術(shù)，在昆蟲和哺乳動物細(xì)胞表達(dá)系統(tǒng)方面積累了豐富的經(jīng)驗，能夠制備高活性、高純度的藥物靶點(GPCR蛋白)，用于下游功能鑒定、結(jié)構(gòu)分析等定制化服務(wù)。

基于冷凍電鏡的GPCR結(jié)構(gòu)解析

康體生命依托世界一流的冷凍電子顯微鏡平臺，分析GPCR與藥物候選分子復(fù)合物的高分辨率結(jié)構(gòu)，為下游AI藥物篩選和基于結(jié)構(gòu)的藥物分子發(fā)現(xiàn)提供豐富且關(guān)鍵的結(jié)構(gòu)生物學(xué)信息。

靶向GPCR的納米抗體藥物發(fā)現(xiàn)

康體生命擁有成熟的納米抗體藥物發(fā)現(xiàn)平臺和羊駝養(yǎng)殖基地，可使用天然庫或免疫庫篩選能夠調(diào)節(jié)GPCR靶點活性的新功能納米抗體候選藥物。

康體生命一一助力靶向GPCR的新藥研發(fā)

康體生命以世界領(lǐng)先的納米抗體發(fā)現(xiàn)平臺為基礎(chǔ)，結(jié)合計算生物學(xué)、結(jié)構(gòu)生物學(xué)和分子藥理學(xué)等前沿技術(shù)，創(chuàng)建了靶向GPCR的藥物發(fā)現(xiàn)平臺，并致力于提供高效的靶向GPCR納米抗體篩選等CRO服務(wù)，為GPCR結(jié)構(gòu)解析及新藥研發(fā)再添助力。

提供一站式高活性GPCR表達(dá)、純化及結(jié)構(gòu)鑒定服務(wù)
GPCR功能驗證服務(wù)
冷凍電鏡中心
基于GPCR結(jié)構(gòu)的藥物發(fā)現(xiàn)
我們將在項目的每一階段生成項目進(jìn)度報告

GPCR蛋白產(chǎn)品列表

Class A GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
0PRM1	opioid?receptor	human	HEK293/Sf9	full?length
0PRL1	opioid?receptor	human	HEK293/Sf9	full?length
0PRK1	opioid?receptor	human	HEK293/Sf9	full?length
0PRD1	opioid?receptor	human	HEK293/Sf9	full?length
CCR2	Chemokine?Receptor	human	HEK293/Sf9	full?length
CCR4	Chemokine?Receptor	human	HEK293/Sf9	full?length
CCR5	Chemokine?Receptor	human	HEK293/Sf9	full?length
CCR6	Chemokine?Receptor	human	HEK293/Sf9	full?length
CCR7	Chemokine?Receptor	human	HEK293/Sf9	full?length
CCR9	Chemokine?Receptor	human	HEK293/Sf9	full?length

Class A GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
V2R	Vasopressin?receptor	human	HEK293/Sf9	full?length
5-HT 1A	Serotonin receptor	human	HEK293/5f9	full length
5-HT1B	Serotonin receptor	human	HEK293/Sf9	full length
MTR1A	Melatonin receptor	human	HEK293/Sf9	full length
MTR1B	Melatonin receptor	human	HEK293/Sf9	full length
ADAZA	Adrenergic receptol	human	HEK293/5f9	full length
ADA2B	Adrenergic receptol	human	HEK293/Sf9	full length
ADA2C	Adrenergic receptol	human	HEK293/5f9	full length
ADRB1	Adrenergic receptol	human	HEK293/Sf9	full length
ADRB2	Adrenergic receptol	human	HEK293/Sf9	full length

Class A GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
CXCR1	Chemokine Receptor	human	HEK293/Sf9	full length
CXCR2	Chemokine Receptor	human	HEK293/5f9	full length
CXCR3	Chemokine Receptor	human	HEK293/Sf9	full length
CXCR4	Chemokine Receptor	human	HEK293/5f9	full length
CXCR5	Chemokine Receptor	human	HEK293/Sf9	full length
DRD1	Dopamine receptor	human	HEK293/Sf9	full length
DRD2	Dopamine receptor	human	HEK293/Sf9	full length
DRD3	Dopamine receptor	human	HEK293/5f9	full length
MC3R	Melanocortin receptor	human	HEK293/Sf9	full length
MC4R	Melanocortin receptor	human	HEK293/Sf9	full length

Class A GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
OXTR	Oxytocin?receptor	human	HEK293/Sf9	full?length
GHSR	Ghrelin?receptor	human	HEK293/Sf9	full?length
CB1	Cannabinoid?receptor	human	HEK293/Sf9	full?length
CB2	Cannabinoid?receptor	human	HEK293/Sf9	full?length
CCKAR	Cholecystokinin?receptor	human	HEK293/Sf9	full?length
CCKBR	Cholecystokinin?receptor	human	HEK293/Sf9	full?length
0X1R	Orexin?receptor	human	HEK293/Sf9	full?length
0X2R	Orexin?receptor	human	HEK293/Sf9	full?length
PTGDR2	prostaglandin?receptor	human	HEK293/Sf9	full?length
PTGDR3	prostaglandin?receptor	human	HEK293/Sf9	full?length
PTGDR4	prostaglandin?receptor	human	HEK293/Sf9	full?length

Class B GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
VIP2R	Vasoactive?intestinal?polypeptide?rece?ptor	human	HEK293/Sf9	full?length
VIP1R	Vasoactive?intestinal?polypeptide?rece?ptor	human	HEK293/Sf9	full?length
AMY3R	Amylin?receptor	human	HEK293/Sf9	full?length
AMY2R	Amylin?receptor	human	HEK293/Sf9	full?length
AMY1R	Amylin?receptor	human	HEK293/Sf9	full?length
CRF2R	Corticotropinreleasing?hormone?receptor	human	HEK293/Sf9	full?length
CRF1R	Corticotropinreleasing?hormone?receptor	human	HEK293/Sf9	full?length
AM2R	Adrenomedullin?receptor	human	HEK293/Sf9	full?length
AMIR	Adrenomedullin?receptor	human	HEK293/Sf9	full?length
PTH2R	Parathyroid?hormone?receptor	human	HEK293/Sf9	full?length

Class B GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
PTH1R	Parathyroid?hormone?receptor	human	HEK293/Sf9	full?length
CRHR2	Corticotropin?releasing?hormone?rece?ptor	human	HEK293/Sf9	full?length
CRHR1	Corticotropin?releasing?hormone?rece?ptor	human	HEK293/Sf9	full?length
CALCR	Calcitonin?receptor	human	HEK293/Sf9	full?length
GHRHR	Glucagon?receptor	human	HEK293/Sf9	full?length
GIPR	Glucagon?receptor	human	HEK293/Sf9
GLP2R	Glucagon?receptor	human	HEK293/Sf9	full?length
GLP1R	Glucagon?receptor	human	HEK293/Sf9	full?length
GCGR	Glucagon?receptor	human	HEK293/Sf9	full?length
SCTR	Secretin?receptor	human	HEK293/Sf9	full?length

Class C GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
CASR	Calcium-sensing?receptor	human	HEK293/Sf9	full?length
GPRC6A	opioid?receptor	human	HEK293/Sf9	full?length
GPRC5D	Glucagon?receptor	human	HEK293/Sf9	full?length
GPRC5C	Chemokine?Receptor	human	HEK293/Sf9	full?length
GPRC5B	Glucagon?receptor	human	HEK293/Sf9	full?length
GPRC5A	Glucagon?receptor	human	HEK293/Sf9	full?length
GPR179	opioid?receptor	human	HEK293/Sf9	full?length
GPR158	opioid?receptor	human	HEK293/Sf9	full?length
GPR156	opioid?receptor	human	HEK293/Sf9	full?length
TAS1R3	Taste?receptor	human	HEK293/Sf9	full?length
TAS1R2	Taste?receptor	human	HEK293/Sf9	full?length

Class C GPCR (Rhodopsin-like family)
Receptor	Receptor family	Species	Expression system	Description
TAS1R1	Taste?receptor	human	HEK293/Sf9	full?length
mGluR7	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
mGluR6	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
mGluR5	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
mGluR4	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
mGluR3	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
mGluR2	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
mGluRI	Metabotropic?glutamate?receptor	human	HEK293/Sf9	full?length
GABBR2	Gamma-aminobutyric?acid?receptor	human	HEK293/Sf9	full?length
GABBR1	Gamma-aminobutyric?acid?receptor	human	HEK293/Sf9	full?length
CASR	Calcium-sensing?receptor	human	HEK293/Sf9	full?length

納米抗體技術(shù): 羊駝駱駝免疫; 文庫構(gòu)建; 抗體篩選; 蛋白表達(dá)純化; 親和力檢測 (BLI); 人源化與親和力成熟

蛋白表達(dá)純化: E.coli表達(dá)系統(tǒng); 酵母表達(dá)系統(tǒng); 哺乳動物細(xì)胞表達(dá)系統(tǒng); 昆蟲細(xì)胞表達(dá)系統(tǒng)

產(chǎn)品分類: 納米抗體系列; 重組標(biāo)簽蛋白抗體; 蛋白純化填料系列; 感受態(tài)細(xì)胞系列; 鏈霉親和素系列; SDS-PAGE/WB相關(guān)產(chǎn)品; PCR系列; 自動誘導(dǎo)培養(yǎng)基; 分子診斷酶; 逆轉(zhuǎn)錄系列; 抗體制備相關(guān)產(chǎn)品; 羊駝天然文庫; 重組蛋白酶

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